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5, 7, 10, 13 – 20 SCs were also reported to be associated with a wide range of positive and negative symptoms and cognitive impairment that resemble the phenomenology of schizophrenia. SCs are shown to trigger psychotic symptoms including paranoia, hallucinations, disorganized behavior, and suicidal thoughts among individuals with or without concomitant psychiatric disorders. 1, 5, 11, 12 Hence, SCs may induce a more severe clinical presentation than the natural plants they are supposed to mimic, including agitation, anxiety, tachycardia, hallucinations, irritability, memory and cognitive impairment, violent behavior, unresponsiveness, and psychosis.
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10 Whilst purchased and perceived as risk-free marijuana-like herbal blends, 1 SCs are much more potent than natural cannabis, since they act as a more potent full agonist at the cannabinoid subtype 1 receptor than THC, and they also lack cannabinoids such as CBD that may otherwise counteract psychoactive properties of THC. 5 – 9Ĭannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) are the two principal ingredients of natural cannabis (marijuana) with counteracting functions.
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1 – 5 Albeit no data are available on the exact prevalence of SC use in Turkey, a rapidly growing increase in SC consumption among young population has been noted in Turkey consistent with the global increase in the prevalence of SC use among adolescents and young adults with a male predominance. Consumption of synthetic cannabinoids (SCs), marketed under different names such as K2, Spice, Aroma, and Dream in different countries and named as Bonzai in Turkey, has been increasing worldwide.